Azeb Mesfin is a widow of the late Ethiopian Prime Minister Meles Zenawi. Together they had three children; Semhal, Marda and Senay Meles.
Azeb was elected to the House of Peoples’ Representatives, in 2005 and 2010, representing her home district of Wolkait and Humera, and served as chair of its Social Affairs Standing Committee. In 2013, she was elected to the council of Addis Ababa City Administration. She is member of the executive committee of TPLF and EPRDF since 2010. She was elected to the council of Addis Ababa City Administration in 2013.
Azeb is also the CEO of the TPLF parastatal conglomerate EFFORT.